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Standards of medical care in diabetes-2006. Diabetes Care.

As glucose levels rise above 180 mg per dL in these at risk cells, reactive oxygen species (ROS) form within their mitochondria electron transport chain, triggering a cascade of events leading to microvascular and macrovascular disease. 40 The downstream targets of ROS formation include increased activity of protein kinase C (PKC), activation of nuclear factor (NF)- B, collagen synthesis, and cell death. 225 Exposure to blood glucose levels above 180 mg per dL for just 4 hours can cause the downstream effects of ROS to persist for up to 7 days, even if the blood glucose levels are quickly normalized.

The products print using thermo plastics and will be largely used for prototyping rather than end-use applications.]