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In-hospital and 6-month mortality double that in nondiabetics Complications (e.arrhythmias, heart failure, death) more common Reperfusion rates after thrombolysis are similar to those of nondiabetics, but reocclusion and reinfarction rates are higher. Mortality reduced by insulin glucose infusion immediately after myocardial infarction. 5-y survival rates after coronary artery bypass graft or percutaneous coronary angioplasty lower than for nondiabetics 5-y survival better after coronary artery bypass graft than percutaneous coronary angioplasty because of higher restenosis rates. Atheromatous disease in the legs, as in the heart, tends to affect more distal vessels (e.the tibial arteries), producing multiple, diffuse lesions that are more challenging to bypass or dilate by angioplasty than are more proximal vessels with hemonline pfizer viagra lesions. Vascular disease and endothelial dysfunction appear to be accelerated in diabetes due to the multiple metabolic anomalies associated with hyperglycemia. Damaged endothelial cells produce lower levels of nitric oxide, thereby inhibiting vasodilation. Vascular smooth-muscle proliferation in association with higher circulating levels of plasminogen activator inhibitor-1 (PAI-1) leads to a state of hypercoagulation, increased thrombosis, and progressive atherogenesis.

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Due to the issuance of these shares in 2000, the Company then reclassified the contingent shares to additional paid in capital. In March 2000, pursuant to a termination and settlement agreement, the new Chief Executive Officer transferred 1,000,000 shares of his personally held common stock to an ex-officer of the Company. The shares were valued at 1,720,000, which was the fair value of the stock at the date of the agreement. From time to time the Company may become a party to legal proceedings that are routine litigation incidental to its business.

ARBs. can be used as a first-line antihypertensive agent in patients unable to tolerate ACE inhibitors.]