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Intensively managed patients achieved an average A1C that was, on average, 2. 1 lower than that of their conventionally managed counterparts. Table 11-3 outlines the microvascular disease state risk reductions associated with a 2 lowering of one's A1C. When speaking to patients regarding the positive outcomes associated with intensive diabetes management, the importance of statistics is often lost in the details.

AGEs are forming, increasing oxidative stress in sensitive tissues. Irreversible complications are beginning to take hold. The opportunities to intervene, reverse, or delay these pathologic events are vanishing along with the patient's normal endothelial cell and beta-cell functioning.

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